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KMID : 0613820060160010168
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Journal of Life Science
2006 Volume.16 No. 1 p.168 ~ p.174
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Molecular Engineering of Epoxide Hydrolases for Production of Enantiopure Epoxides
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Kim Hee-Sook
Lee Eun-Yeol
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Abstract
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Enantiopure epoxides are valuable intermediates for the asymmetric synthesis of enantiopure bioactive compounds. Microbial epoxide hydrolases (EHs) are versatile biocatalysts for the preparation of enantiopure epoxides by enantioselective hydrolysis of cheap and easily available racemic epoxide substrates. EHs are commercially potential biocatalysts due to their characteristics such as high enantioselectivity, cofactor-independent catalysis, and easy-to-prepare catalysts. In this paper, recent progresses in molecular engineering of EHs are reviewed to evaluate the commercial feasibility of EH-catalyzed hydrolytic kinetic resolution for the production of enantiopure epoxides.
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